No matter what you may assume, you need to absolutely follow their guidelines, if you stand any chance of being seen in a sea of monthly manuscript submissions. Publishing companies all have their own submission requirements. It is important to check the fine details before submitting your work. They are all respected publishers with good reputations. Here are fifteen publishers who are always open to submissions from writers with or without agents and with or with no previous publishing experience. It can be confusing knowing when to submit. Many publishers routinely open and close their doors to unsolicited submissions.